Part 4: Transcribing And Translating | Answer Key

University:
Santa Ana College
Course:
BIOL 109 | Fundamentals of Biology
Academic year:

2025
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301

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1
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reeses puffies

Biolnteractive Why Do Some People with the Sickle Cell Genotype Not have Symptoms? PART 4: Transcribing and Translating Below are parts of the DNA sequence for the HBB gene. There are two tables: one for the typical gene and one for the gene with the mutation that can lead to sickle cell disease. The sequences are broken into groups of three nucleotides each, called codons For each table, you will transcribe the DNA into RNA. Then, you will translate the RNA into amino acids using the "Genetic Code Chart," which will be provided by your instructor. 13. Below the DNA sequence in Table 2, record the appropriate mRNA and amino acid sequences. Table 2. Part of the typical HBB gene sequence. Codon Number 1 2 3 4 5 6 7 DNA MRNA GUG Amino acid CAC GTG CBC. GAC CUG TGA GGA CTT CTC val His Leu ACU Thr Pro GAA GAG GIU Glu 14. Below the DNA fragment in Table 3, record the appropriate mRNA and amino acid sequences. Table 3. Part of the HBB gene sequence with the mutation that can lead to sickle cell disease. Codon Number 1 2 3 4 5 6 7 DNA CAC GTG GAC TGA GGA CAT CTC mRNA GUG CAC CUG ACU CCU GUA GAG Amino acid Val Pro His Leu Tur Pro Vai 15. Based on your results above: a. Describe any differences between the "typical" and "sickle cell HBB gene sequences. Include the numbers of any affected codons. Changed Only 1, CTT changed to CAT (codon 6). b. is the mutation that occurred an addition, deletion, substitution, or inversion? Substitution c. How did the mutation impact the resulting amino acid sequence? It changed it frown Glu to Val.

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